You know there's two big posts there about the Malnosso and conflict and then there's this, and I think I would second the idea of the Malnosso being unethical and build towards making choices with them. Honestly, I'd really like to see the villagers here (because we're a notably important group in this enclosure) do things like get mixed up in the direct nature of inter-Organization politics (in-fighting factions), or perhaps even select individuals or select groups being taken in for internship type positions.

Like... one admittedly long off idea I had in mind is the ethical issue of what if some person or body of player-characters was put in charge of or played a role in picking what experiments are put onto another enclosure (say, #7 or #8) and they are obligated (either through administrative hoo-hah, defense of their own enclosure, or perhaps some garble like Natural Shifts would ravage them without habitual manmade ones) to do so.

Have the Malnosso Organization take up the role of shady big brother and play it straight-er than it is now.